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KMID : 0376219920290010115
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Chonnam Medical Journal
1992 Volume.29 No. 1 p.115 ~ p.122
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The effects of midazolam and thiopental as an anesthetic induction agent
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Abstract
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The purpose of this study was to evaluate the properties of midazolam and thiopental as an induction agent.
Sixty healthy adult patients, scheduled for elective surgery under general anesthesia were randomly assigned to receive either thiopen-tal 5mg/kg (group 1, n=30) or midazolam 0.15mg/kg (group 2, n=30) as an induction agent. Anesthesia was
maintained
with 1.0% halothane and 50% N2O in O2.
Induction time, systolic and diastolic blood pressure, and heart rate were measured in each group during anesthesia, and frequency of local venous complication was evaluated.
The time from the start of injection to spontaneous closing of eyes and to loss of eyelid reflex of group 2 (84.6±10.7 secs, 98.9±10.0 secs, respectively) was longer than those or group 1 (36.4±2.4 secs, 43.5±2.9 secs, respectively).
Incidence of apnea in group 2 (29/30) was lower than in group 1(22/30).
Systolic pressure decreased significantly in both group, heart rate increased significantly in group 1, but other hemodynamic parameters did not change in both groups. The mangitude of fall in systolic pressure was not significantly differnece
between
two groups.
Incidence of pain during injection was mil in group 2 and 20% in group 1.
On the basis of these data, this result suggest that midazolam is safe and effective induction agent, so may offer alternative to thiopental in situation that hemodynamic stability is maintained.
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KEYWORD
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